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Exhaled nitric oxide (eNO),which reflects eosinophilic irritation of the lower respiratory tract ,showed vital modifications with a rise at 3 months that could point out aspirin-induced mast cell degranulation within the lower respiratory tract by aspirin swallowed after nasal insertion, however this was reversed with additional treatment and increased dose of lysine aspirin with a big lower at 12 months, maintained in patients continued on LAS therapy (data not proven).
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