It may lastly be time to acknowledge that dieting isn't the panacea we hoped it would be. The exception to the rule is the DOT1 household, members of which methylate K79 in the globular area of histone H3 and which are structurally not related to SET-domain proteins 4 - 6 Recent work means that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later)